Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters

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Figure 5.
Figure 5.

Use of a distal CGI as an alternative promoter by MethExp genes in cancer. The figure shows four lines of evidence supporting the usage of a distal CGI as alternative promoter by MethExp genes in contrast to MethNotExp genes in (A) breast and (B) kidney cancer. Each panel shows the distribution of the median (1) fractional methylation at upstream CGIs (top left), (2) genomic distance between distal CGI and gene (bottom left), (3) RNA-seq RPKM signal (top right), and (4) RNA-seq coverage (bottom right) at the segment region (y-axes) corresponding to MethExp (yellow) vs. MethNotExp genes (red) across 100 representative samples (x-axes).

This Article

  1. Published in Advance February 21, 2017, doi: 10.1101/gr.212050.116 Genome Res. 27: 553-566

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