(A) For genes impacted by differential RNA editing, enrichment for de novo mutations from patients with epileptic encephalopathy (EE), autism spectrum disorder (ASD), intellectual disability (ID), and schizophrenia (SCZ); enrichment of association to genetic generalized epilepsy (“Epilepsy GWAS”) and enrichment for known epilepsy genes (Epilepsy Genes) (as defined by DisGeNET). (B) Table summarizes the enrichment P-value, odds ratio (OR), and 95th percentile of the confidence interval of the OR and lists the genes contributing to the enrichment of EE de novo mutations (top) and known epilepsy genes (bottom) among genes differentially RNA-edited in epilepsy.
