A GC-rich sequence feature in the 3′ UTR directs UPF1-dependent mRNA decay in mammalian cells

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Figure 6.
Figure 6.

Model for the mechanism of UPF1-dependent mRNA decay. UPF1 protein is loaded onto target mRNAs via translation and then translocates over the 3′ UTR. In non-GC-rich regions (left), UPF1 is removed from mRNAs. In contrast, in GC-rich regions (right), UPF1 stalls at CUG-centered GC-rich motifs, which promotes mRNA decay.

This Article

  1. Published in Advance December 9, 2016, doi: 10.1101/gr.206060.116 Genome Res. 27: 407-418

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