TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

Validation of model predicting TRUB1 sites. (A) Percentage of control sites identified as being putatively pseudouridylated in either the Carlile et al. or Li et al. data sets, calculated across six bins of the logistic regression-based score. (B) Correlation of the logistic score with sites identified in mouse. Fraction of sites with experimentally measured pseudouridine are depicted across five bins of increasing logistic scores. (C) Ψ levels (captured by med-Ψ-ratios) in mouse, shown across the five bins in B.

This Article

  1. Genome Res. 27: 393-406

Preprint Server