Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

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Figure 6.
Figure 6.

Summary of hairpin features influencing processing. Diagram of hairpin features that influence processing. An optimal stem length of 36 ± 3 nt is favorable for processing, and the appearance of bulges in the two bulge-depleted regions inhibits processing. The CNNC motif preferentially enhances the processing of optimal length pri-miRNAs and has to locate within a distance limit from the base of the hairpin. In addition, other primary sequence motifs and structural features, including basal UG, apical UGU/UGUG, loop size, and a bulge-enriched region, are highlighted.

This Article

  1. Published in Advance January 13, 2017, doi: 10.1101/gr.208900.116 Genome Res. 27: 374-384

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