Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution

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Figure 5.
Figure 5.

A model offering a mechanistic explanation for the role of light-strand transcription pausing. Presented are the stages right after transcription initiation of the light strand, as well as the suggested role for our discovered transcription pausing site. (Alternative products) Replication-based and transcription-based products (i.e., DNA and RNA products, respectively) of the light-strand promoter, as both require the same light-strand RNA primer (∼120 nt in length).

This Article

  1. Genome Res. 27: 362-373

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