Figure 5.
The decrease in nucleosome occupancy around origins from G2/M to G1 is pre-RC dependent. (A) The average nucleosome occupancy around ORC-bound origins in wild type (WT, left), orc1-161 (center), and mcm2-AID (right) cells in G1 (blue) and G2/M (red). (B) The degree of nucleosome loss between G2/M and G1 (log2) in WT (left), orc1-161 (center), and mcm2-AID (right) cells. (C) Heat maps of nucleosome occupancy loss at all ORC-bound origins that are ranked by the degree of the loss between G2/M and G1 in WT (left), orc1-161 (center), and mcm2-AID (right) cells. For the purposes of comparison, wild-type profiles are shown again from Figure 4.
