Figure 3.
Nucleosome occupancy in G1 correlates with pre-RC binding. (A) Mcm2-7 ChIP signals (Belsky et al. 2015) were correlated with nucleosome occupancy: (left) heat map of Mcm2-7 signals across all ORC-bound origins, ranked based on nucleosome occupancy; (right) average Mcm2-7 binding aligned at the ACS classified based on nucleosome occupancy, with low H3 in blue, mid H3 in red, high H3 in green, and ORC unbound in purple. (B) Nucleosome occupancy classes were correlated to cell-cycle ORC footprinting data (Belsky et al. 2015). Blue denotes origins with ORC footprints in both G1 and G2, whereas red denotes those with ORC footprints in G1 only.
