Genomic distribution of typical enhancers and SEs. (A) Density plots representing the proportion of genes (y-axis) covered by typical enhancers and SEs in the vicinity of TSSs (x-axis) in zebrafish brain, mouse cerebellum, and human angular gyrus. (B) Proportion of gene bodies overlapping with typical enhancers, SEs, and control regions (y-axis) in different zebrafish, mouse, and human cells and tissues (x-axis). The mean and the standard deviation (black bars) calculated from bootstrap analyses of control regions are shown. All comparisons between typical enhancers and SEs and their controls have significant differences (P-values from z-scores ≤3 × 10−4), with the exception of zebrafish pluripotent state and heart typical enhancers. (NS) Not significant. (C) Distribution of typical enhancer and SE sequences across genomic features. The y-axis shows the percentage of total brain typical enhancer or SE base pairs overlapping the different genomic features represented in the legend. Adult brain data sets for mouse and human correspond to olfactory bulb and cingulate gyrus, respectively.
