APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

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Figure 4.
Figure 4.

Properties of C→G mutations involved in clusters of de novo mutations. (A) Pairs of C→G de novo mutations tend to form strand-coordinated clusters. (B,C) Fractions of different nucleotides at adjacent sites 5′ (B) and 3′ (C) of the mutated position calculated for clustered and dispersed C→G de novo mutations. Vertical bars represent 95% confidence intervals. (*) P < 0.05 (χ2 test).

This Article

  1. Published in Advance December 9, 2016, doi: 10.1101/gr.210336.116 Genome Res. 27: 175-184

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