Clustered mutations in the TpCpW→K context are enriched in strand-coordinated clusters and biased toward the lagging strand. (A–D) Pairs of linked SNPs in contexts prone to APOBEC3A/B-induced mutations tend to be strand coordinated. (E) Strand-coordinated clusters that are composed exclusively of C→K mutations and contain at least six mutations are approximately threefold enriched in mutations in the TpCpW context, compared with noncoordinated clusters. (F–I) Strand-coordinated pairs are biased toward the lagging strand. The axes and notation are as in Figure 1. The P-value is calculated for the differences between the asymmetries of TpCpW→K and VpCpW→K mutations in the regions with the highest fork polarity (i.e., the first and the last bin).
