APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

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Figure 1.
Figure 1.

Mutations in different APOBEC3A/B contexts are more frequent on the lagging strand (A–D). Horizontal axis indicates the propensity of the region of the DNA strand to be replicated as lagging or leading; vertical axis, ratio of the frequencies of the two complementary mutation types on the strand in this category. Vertical bars represent 95% confidence intervals. V corresponds to A, C, or G.

This Article

  1. Published in Advance December 9, 2016, doi: 10.1101/gr.210336.116 Genome Res. 27: 175-184

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