A novel approach for data integration and disease subtyping

Number of patients in each group for each mutated gene for GBM (A) and LAML (B). The horizontal axes represent the count in short-term survival group, while the vertical axes show the count for long-term survival group(s). Interesting genes/variants will appear in the lower right or upper left corners. (A) There are nine patients in group “1-1” that have a mutation in IDH1, while there is no patient in group 2 reported to have any mutation in this gene. Furthermore, all patients in group 1 share exactly the same mutation, rs121913500 (in dbSNP), which is a T replacing a C on Chromosome 2. (B) Mutations in TP53 are associated with short-term survival in LAML.