DAPs exhibit extensive binding colocalization. (A,B) Heatmaps of Spearman correlation matrix of normalized DAP binding intensities at all observed binding sites in the adult/male (A) and child/female (B) liver. (C) Stacked bar plot displaying the number of peaks for each TF. Bars are divided into those that are shared between both replicates of both donors (green), shared between a donor and one replicate of the other donor (purple), or specific to the adult/male (red) or child/female donor (blue). (D) Cumulative number of base pairs covered per binding site included in adult/male liver observed data (red) and null regions (black) matched for length, GC content, and repeat content. (E) Heatmap of a pairwise Spearman correlation matrix, ordered identically to A, indicating the correlation of allele bias in DAPs from the adult donor that overlap a heterozygous SNP for each pair of factors. The color of each panel indicates the strength of the correlation, with gray indicating that less than 25 peaks met inclusion criteria for allele bias analysis for a given pair.
