Recently-active FL-L1 source elements in human populations and cancers. (A) Circos plot of the human genome with coordinates of known active FL-L1 source elements producing 3′ transductions (circles) (Supplemental Table S9). FL-L1s are further separated into one of three categories based on the tissue type(s) in which activity was recorded. The three most active FL-L1 source elements identified in this study are represented as circles corresponding to the colors in Figure 3A. (B) Log-log plot depicting 14 L1 source elements that were active in the germline (this study) and somatic tumors (Tubio et al. 2014). The three most active germline elements (this study) are highlighted according to the colors in Figure 3A and are active in somatic cancers as well. Note that one of the dots represents two separate L1 source elements, as both have the same number of germline and somatic offspring. (C) Comparison of FL-L1 element activity in the cell culture-based retrotransposition assay (percent of L1.3 or L1RP activity, light blue) (Brouha et al. 2002, 2003; Beck et al. 2010) with the total number of offspring identified in this study (light green) and the Tubio et al. study (light orange) (Tubio et al. 2014). Only elements that were active in the germline (this study), cancers (Tubio et al. 2014), and the cell culture-based assay were displayed.
