Figure 5.
Tree reconstruction in the presence of doublet samples. (A) Cell lineage tree with doublets (gray boxes). (B) Mutation tree with true sample attachment. Doublet samples (s3, 
) and (s4, 
) each attach to two different nodes. (C) Mutation matrix with combined mutation states for the doublet samples. Mutations are counted as present in a doublet sample
if present in at least one of the cells. (D) A tree with a recurrence of mutation M2 and no doublets is an alternative explanation for the mutation matrix in C.
