Single-cell sequencing data reveal widespread recurrence and loss of mutational hits in the life histories of tumors

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Figure 2.
Figure 2.

Testing the infinite sites assumption starts from the single-cell mutation data. The data are examined under both the infinite sites model of all trees with no recurrent mutations as well as under the finite sites model of trees with one recurrence. The two competing models of tumor evolution are compared on how well they explain the single-cell data, with one model selected via the Bayes factor.

This Article

  1. Published in Advance October 13, 2017, doi: 10.1101/gr.220707.117 Genome Res. 27: 1885-1894

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