Figure 4.
aFC compared with linear regression slope. (A–C) Slope of linear regression from 10,000 simulated eQTLs generated similarly to data shown in Figure 2. The true aFC value is compared with regression slopes from raw (A), z-scored (B), and log2 transformed (C) data. The color code represents median eGene expression (A) and reference allele frequency (B,C) with alternative color-coding for the same plots in Supplemental Figure S4. (D–F) Regression slope compared with aFC values estimated using GTEx eQTLs data from adipose subcutaneous.
