Cross-tissue comparison of TSN results. (A) Jaccard coefficient quantified on shared edges (upper triangular) and shared nodes (lower triangular) across pairs of TSNs. (B) Gene expression levels, removing factors from BicMix not included in the network, for the genes identified in the TSN for artery–aorta. The y-axis is ordered by similarity to artery–aorta, with a star by the samples from artery–aorta. The colors on the y-axis correspond to the GTEx tissue legend above. The x-axis is ordered by expression similarity (i.e., hierarchical clustering), and hub genes are labeled, with the large hub denoted in bold. (C) TSN for artery–coronary. Node size reflects betweenness centrality of the nodes. Orange nodes reflect replication in the BioCarta acute myocardial infarction (AMI) pathway; orange edges show the neighbors of the AMI pathway nodes.
