Cover image
Pancreatic cancer is characterized by altered distribution of 5-hydroxymethylcytosine (5-hmC) marks. 5-hmC regulates many oncogenic transcripts, including that of the gene encoding the bromodomain-containing transcription factor BRD4. BRD4 inhibition leads to in vivo pancreatic tumor growth inhibition. (Cover illustration by Carlie Hruban. [For details, see Bhattacharyya et al., pp. 1830–1842.])
