Massive reshaping of genome–nuclear lamina interactions during oncogene-induced senescence

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 6.
Figure 6.

Deletion of LBR does not cause OIS-like changes in NL interactions in cycling human HAP1 cells. (A) LMNB1 DamID profiles along Chromosome 7 for wild-type and LBR KO cycling human HAP1 cells. (B) Changes in LMNB1 interaction after LBR KO (top). For comparison, the changes in NL interactions upon OIS (as in Fig. 1C) are shown (bottom). (C) Scatter plot of the ratio of Dam-LMNB1 interaction within 100 kb windows for wild-type (x-axis) and LBR KO cells (y-axis). The circles are colored according to their cLAD/ciLAD/fLAD/fiLAD status.

This Article

  1. Published in Advance September 15, 2017, doi: 10.1101/gr.225763.117 Genome Res. 27: 1634-1644

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research