Transposable elements are the primary source of novelty in primate gene regulation

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Figure 6.
Figure 6.

Regulatory ability of TE families found in poised and active regulatory elements in HepG2 cells. (A) The P-value (Wilcoxon rank-sum test), class, and lineage specificity for the 69 TE families tested in HepG2 cells for regulatory ability, the empty vector control (Basic[minP]), and the positive control (TAP2_C) are all shown above the six luciferase assay replicates conducted and the average regulatory ability found across the replicates. Red indicates luciferase expression higher than the empty vector control; blue indicates luciferase expression less than Basic[minP]. (B) Motifs enriched in the sequences of the 66 TE families that drive expression significantly different from background.

This Article

  1. Genome Res. 27: 1623-1633

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