Fragile nucleosomes are enriched at genes that will be expressed in the future and in specific contexts. Top 10 Gene Ontology biological process functional annotation terms associated with genes with fragile (A) and resistant (B) nucleosomes. (C) Bar plot representation of expression levels and coefficient of variation (CV) for R07H5.2 and F26F2.10. R07H5.2 has a low CV and is an example of a stably expressed gene (yellow); F26F2.10 has a high CV and is an example of a developmentally regulated gene (violet). (D) Average plot of fragility and nucleosome occupancy scores at 1000 stably expressed genes (left) or developmentally regulated genes (right) as determined by their coefficient of variation across seven different life stages: early embryo, late embryo, larval stages L1, L2, L3, L4, and young adult.
