Pairwise correlation of per-insert RNA/DNA ratios between replicates, within and between MT versus WT experiments. The lower left triangle shows pairwise scatter plots. The diagonal provides replicate names and the respective histogram of the RNA/DNA ratios for that replicate. The upper triangle provides Pearson (p) and Spearman (s) correlation coefficients. MT versus MT (green box) or WT versus WT (blue box) comparisons are substantially more correlated than MT versus WT (yellow boxes) comparisons, consistent with systematic differences between the episomal versus integrated contexts for reporter assays that exceed technical noise. The two right-most columns and two bottom-most rows correspond to MT and WT after combining across the three replicates, with the combined MT versus the combined WT comparison in the red box.
