Figure 6.
Evolutionary age and sequence conservation of testis-specific lncRNAs. (A) A simplified phylogenetic tree to illustrate the distribution of functional and dysfunctional lncRNAs. (B) Sequence conservation (15-way PhastCons score) for lncRNAs, with or without knockout phenotypes, and different characteristic genomic regions. PhastCons scores represent probabilities of negative selection (range between 0 and 1) at single-nucleotide resolution. The smaller the divergence of a DNA segment across species, the more likely it is that the segment belongs to a conserved element maintained by negative selection.
