Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

TP53 binding is conserved across data sets. Fifteen public data sets containing ChIP-seq against TP53 under various conditions were collected and remapped (Supplemental Table S7). Throughout the genome, 21,649 predicted TP53 binding sites are clustered based on their coverage across all data sets and can be subdivided into shared strong (green), shared weak (yellow), and shared unbound (red) regions. On the bottom, individual aggregation plots show the coverage for each cluster per sample.

This Article

  1. Genome Res. 26: 882-895

Preprint Server