Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants

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Figure 6.
Figure 6.

Scatter plots of unadjusted SKAT-O P-values against permutation-based P-values for tests of association between coding variation in STAT1 and RNA expression levels of STAT1 target genes. Each point represents a single target gene. (A) P-values for the default parameterization of SKAT-O. (B) P-values for the test with more weight shifted onto rare variants.

This Article

  1. Published in Advance May 18, 2016, doi: 10.1101/gr.202440.115 Genome Res. 26: 863-873

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