A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets

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Figure 6.
Figure 6.

Natural selection on pathways. Estimates of f in EAs and AAs were calculated for nonsynonymous SNVs for genes across all categories in Gene Ontology, KEGG pathways, and Reactome pathways. The number (and proportion) of categories in each of the four quadrants is shown in each panel.

This Article

  1. Published in Advance April 14, 2016, doi: 10.1101/gr.203059.115 Genome Res. 26: 834-843

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