A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets

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Figure 5.
Figure 5.

Relationship between predicted pathogenicity of SNVs and estimate of f in populations. The average estimate of f on nonsynonymous (A) and synonymous (B) SNVs was computed on each bootstrapped subset of SNVs in each bin by using a quantile-binning approach, such that each bin had the same number of SNVs. Error bars, SEM scaled C-score (x-axis) and mean estimate of f (y-axis). The red (EA) and blue (AA) lines represent the best fit curves to the data.

This Article

  1. Published in Advance April 14, 2016, doi: 10.1101/gr.203059.115 Genome Res. 26: 834-843

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