Figure 4.
Deletion of Spt4 results in genome-wide increase in Pol II density within gene bodies of S. cerevisiae and S. pombe. (A,B) MA plots showing the DESeq2-based differential expression analysis of spike-in normalized PRO-seq read-counts within the gene bodies of S. cerevisiae (A) and S. pombe genes (B). (C,D) Example of spt4Δ affected gene in S. cerevisiae (C) and S. pombe (D). Browser tracks correspond to PRO-seq data derived separately from two biological replicates of WT (green) and spt4Δ (red) in budding and fission yeast.
