Figure 4.
Expression of CREs with only KLF4 binding sites in overexpression backgrounds. Expression of the basal promoter and CREs with one to six KLF4 binding sites in each of the four overexpression (OE) conditions. Expression represented as mean ± SEM (Supplemental Data S1). See text for relevant statistical comparisons. Expression of the Klf genes in the OE conditions can be found in Supplemental Figure S5. Notably, Klf4 and Klf5 are both overexpressed in the Klf5 overexpression condition. The expression predictions of the thermodynamic model can be found in Supplemental Figure S6. Biochemical signal of clusters of KLF4 sites in the genome can be found in Supplemental Figure S7.
