Impact of the X Chromosome and sex on regulatory variation

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Figure 5.
Figure 5.

Disease associated variants with sex-biased eQTLs. Proportion of independent (LD-pruned) variants with higher eQTL effect sizes in females for GWAS variants of traits in ImmunoBase. Each trait variant tested had to be a significant eQTL variant (nominal P-value < 0.001). Red data points indicate traits with eQTL effect sizes that are significantly different between sexes (Bonferroni adjusted P-value < 0.05). (ATD) Autoimmune thyroid disease, (CEL) celiac disease, (JIA) juvenile idiopathic arthritis, (MS) multiple sclerosis, (PBC) primary biliary cirrhosis, (PSO) psoriasis, (RA) rheumatoid arthritis, (RND) random eQTL variants, (T1D) type 1 diabetes.

This Article

  1. Genome Res. 26: 768-777

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