Discovery of sex-specific chromatin accessibility regions. (A) QQ plot for tests of differential chromatin accessibility between the sexes. 95% genome-wide confidence interval in gray. (B) Enrichment of genes with differential expression between the sexes (FDR 5%) with differential chromatin accessibility (varying thresholds) 40 kb upstream. (**) P-value < 10−5, (*) P-value < 10−3, Fisher's exact test. (C) Proportion of sex-interacting eQTL genes (P-value < 0.05) in differential chromatin accessibility regions (varying thresholds). (*) P-value < 5.0 × 10−2, Fisher's exact test. (D) Chromatin accessibility peak located at Chr 7: 95,063,722–95,064,222 and 5000 bp upstream and downstream. This region has differential chromatin accessibility between males and females (nominal P-value = 4.1 × 10−4, Q-value = 7.5 × 10−2). (E) Sex-interacting eQTL for PON2 and rs35903871 located at Chr 7: 95,063,972 (nominal P-value = 8.0 × 10−3).
