Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy

Parental genomes are segregated in distinct cell lineages following normal fertilization. (A) Genome-wide paternal and maternal haplarithms of three blastomeres derived from the same monospermic embryo (E19_BRP012) demonstrate that the same parental genomes (same HR profiles across each parental genome) segregated into three distinct lineages (top: gynogenetic; middle: androgenetic; bottom: biparental) (see also Fig. 3A). Note that here, option 2 of siCHILD was applied (see Methods). (B) Circos plot illustrating the genome-wide interpreted copy-number profiles of all the single blastomeres derived from embryo E19_BRP012.