Mingkun Li; Rebecca Rothwell; Martijn Vermaat; Manja Wachsmuth; Roland Schröder; Jeroen F.J. Laros; Mannis van Oven; Paul I.W. de Bakker; Jasper A. Bovenberg; Cornelia M. van Duijn; Gert-Jan B. van Ommen; P. Eline Slagboom; Morris A. Swertz; Cisca Wijmenga; Genome of the Netherlands Consortium; Manfred Kayser; Dorret I. Boomsma; Sebastian Zöllner; Peter de Knijff; Mark Stoneking; Genome of the Netherlands Consortium; Manfred Kayser; Dorret I. Boomsma; Sebastian Zöllner; Peter de Knijff; Mark Stoneking

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

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Figure 6.

Likelihood curves for the observed data (changes in MAF from mothers to offspring) under different models for the transmission of mtDNA. (A) Likelihood curve for the constant-size bottleneck model with mtDNA genomes as segregating units. (B) Likelihood curve for the variable-size bottleneck model with mtDNA genomes as segregating units. (C) Likelihood curve for the constant-size nucleoid model. (D) Likelihood curve for the variable-size nucleoid model.