Quantitative BrdU immunoprecipitation method demonstrates that Fkh1 and Fkh2 are rate-limiting activators of replication origins that reprogram replication timing in G1 phase

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Figure 3.
Figure 3.

Fkh1-OE stimulates origin firing. (A) Origins were divided into quartiles according to TRep, and BrdU incorporation was averaged across 10-kb regions aligned by the peak summit of each origin. (B) TRep distributions of all origins and those classified as Fkh1-OE-activated and Fkh1-OE-repressed. (C) Average BrdU incorporation for 10-kb regions aligned by the peak summit of all origins and those classified as Fkh1-OE-activated and Fkh1-OE-repressed.

This Article

  1. Published in Advance January 4, 2016, doi: 10.1101/gr.196857.115 Genome Res. 26: 365-375

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