Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression

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Figure 9.
Figure 9.

Analysis of replication profiles and checkpoint response in the wild type, single, double, and triple mutants with mcm4Δ74-174, sld3-38A, and/or dbf4-19A alleles. (A,B) Yeast cells were synchronized in G1 phase and released into YPD containing 0.05% MMS and 0.5 mM EdU for 50 min. (A) Replication profiles of Chromosome IV. (B) Distribution of fork progression constructed as in Figure 4B. (C) Cells from the indicated strains were synchronized in G1, released into YPD containing 0.05% MMS, and analyzed as in Figure 8C.

This Article

  1. Published in Advance January 5, 2016, doi: 10.1101/gr.195248.115 Genome Res. 26: 315-330

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