EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Locus-specific control of DNA methylation imprints by EHMT2 at the Slc38a4 gDMR. (A) Methylation scores measured by RRBS in 16 known imprinted gDMRs in WT and Ehmt2−/− embryos. (B) Bisulfite cloning and sequencing analysis of four gDMRs in WT and Ehmt2−/− E9.5 embryos. (C) MeDIP profiles at the imprinted Slc38a4 locus (top) and RRBS scores in four WT and three Ehmt2−/− embryos (bottom). The orange rectangle marks the position of the gDMR.

This Article

  1. Published in Advance November 17, 2015, doi: 10.1101/gr.198291.115 Genome Res. 26: 192-202

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research