EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos

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Figure 1.
Figure 1.

Global impact of EHMT2 on the DNA methylome of mouse ESCs. (A) Density histograms of RRBS methylation scores at CpGs in WT ESCs, Ehmt2−/− ESCs, and Ehmt2−/− ESCs rescued with a WT Ehmt2 transgene (Tg). (B) Average distribution of RRBS methylation over RefSeq genes and flanking sequences in WT, Ehmt2−/−, and Ehmt2 rescued ESCs. (C) Heatmap representation of the RRBS methylation scores measured in the promoters (−1000 to +1000 bp) of selected germline and developmental genes. (D) Violin plots of RRBS methylation scores in retrotransposons.

This Article

  1. Published in Advance November 17, 2015, doi: 10.1101/gr.198291.115 Genome Res. 26: 192-202

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