APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

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Figure 5.
Figure 5.

Mutation rates of 5-methylcytosines versus nonmethylated cytosines at CpG sites. (A) APOrich tumors. (B) Tumors with rapo < 2. Methylation (Meissner et al. 2008) and mutation (WGS) data sets are tissue matched. Vertical bars represent 95% confidence intervals.

This Article

  1. Published in Advance January 11, 2016, doi: 10.1101/gr.197046.115 Genome Res. 26: 174-182

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