Figure 3.
Mutations in early versus late replicating regions. Horizontal axis: genome split into 10 bins of equal size from early to late RT. (A) Mutation rates as a function of replication time (RT), relative to the mutation rate in the early RT bin. (B) Percentage of mutations in exons that fall into this bin (among all mutations in the genome) as a function of RT. Three percent of mutations in APOrich tumors and only 2.3% of mutations in APOpoor tumors occur in exons. Vertical bars represent 95% confidence interval.
