Motifs for the 131 C2H2-ZF proteins analyzed by ChIP-seq. Motifs are identified using either MEME or RCADE (see Supplemental Methods). The area under the ROC curve (AUC) of each motif for distinguishing top 500 peaks from dinucleotide-shuffled sequences is shown, along with the log odds sequence logo of the motif. For proteins whose motif-containing peaks overlap significantly with repeat elements at FDR <0.01, the repeat type with the most significant enrichment (i.e., the smallest P-value) is shown on the right. The squares on the left of the proteins represent effector domains. For ZNF394 both the ChIP-seq motif (top) and the HT-SELEX motif (bottom) are shown. See also Supplemental Figure S2, Supplemental Tables S2 and S3.
