Improved assembly of noisy long reads by k-mer validation

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Figure 4.
Figure 4.

Contiguity of assemblies produced with different methods. (M) standard MHAP; (L) MHAP with low-frequency k-mer masking; (LH) MHAP with low and high frequency k-mer masking. (A) Assembly of simple genomes under the challenging conditions of low coverage (E. coli; coverage reduced from 94× to 30×) or small sketch size (yeast; MHAP sketch size reduced from 512 to 128). (B) Assembly of three complex genomes (C. elegans, A. thaliana, and D. melanogaster).

This Article

  1. Published in Advance October 7, 2016, doi: 10.1101/gr.209247.116 Genome Res. 26: 1710-1720

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