A privacy-preserving solution for compressed storage and selective retrieval of genomic data

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Figure 2.
Figure 2.

Storage analysis of compression algorithms for genomic data. (A) Storage comparison on simulated data sets. It shows the average number of bits per base (compression ratio) for three storage formats: BAM, CRAM, and SECRAM. The results are based on simulated data sets with different coverages (from one to 50) and error rates (0.01%, 0.1%, 1%) for both paired and unpaired data. (B) Storage comparison on Chromosome 11 from the 1000 Genomes Project participants with an average coverage of 3×. Only SECRAM is an encrypted format, whereas both BAM and CRAM are in plaintext. Both A and B show that the compression ratio of SECRAM is between that of BAM and that of CRAM.

This Article

  1. Published in Advance October 27, 2016, doi: 10.1101/gr.206870.116 Genome Res. 26: 1687-1696

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