Figure 3.
Stop codon readthrough likely enables translation of nonsense variant–containing mRNAs. Ribosome profiling read coverage of nonsense variants lying within PVRIG (A) and SLFN13 (B). Units and data normalization are as in Figure 2. Bottom plots are zoomed-in versions of the top plots. (Green bars) ATG start codons. (Full/half-height green bars) ATG codons that are/are not within a Kozak consensus context, defined as RnnATGG (R = A/G).
