A generic, cost-effective, and scalable cell lineage analysis platform

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Figure 2.
Figure 2.

Cell lineage analysis of a controlled ex vivo tree. Schematic representation of the ex vivo SC clone tree experiment. (A) Single cells are picked from a plate to form colonies. After a limited number of cell divisions, cells are picked from each clone to form SC subclones. Repeating this step generates a SC clone tree with a known structure. (B) Collaterally, in each passage in which single cells are selected for SC subcloning, single cells are picked to a PCR plate for WGA and subsequent cell lineage analysis.

This Article

  1. Published in Advance August 24, 2016, doi: 10.1101/gr.202903.115 Genome Res. 26: 1588-1599

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