Figure 6.
Patient data indicate that E/R-perpetuated changes persist at diagnostic samples. (A) Expression of ITGA4 and LAT2 in microarrays shows repression among E/R-positive patients compared to other subtypes: (MLL) KMT2A (MLL) rearranged; (HD) hyperdiploid; (HSC) hematopoietic stem cells. In each comparison, statistical significance (Mann-Whitney U test) was tested against the E/R-positive subtype: (***) P < 0.001; (**) P < 0.01; (*) P < 0.05. (B) Concordance between differentially expressed genes on GRO-seq and combined microarray (Pearson's correlation coefficient 0.529, P = 0.0011) (Supplemental Table S7).
