Figure 3.
Inhibition of miR-128 increases neuronal activity. (A) MFR, (B) burst rate, and (C) number of network spikes of miR-128 knockdown cultures (red) are significantly increased in comparison to control cultures (black) between DIV8 and DIV16. The x-axis on all charts is DIV3 to DIV19. Data are represented as the mean of 17 wells transduced with the control nontargeting shRNA (n = 17) and 16 wells transduced with the miR-128 sponge (n = 16) ± SEM. P-values determined using permutation test (Supplemental Methods).
