Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin

The GG-NER pathway coordinates lesion removal by controlling UV-induced histone H3 acetylation in genomic domains around Abf1 binding sites. (A) Rad16-dependent repair (purple line) and UV-induced H3Ac (orange line) are shown here. The shading highlights the domain where these processes are controlled by the GG-NER complex, initiated from sites of Abf1 binding. (B) Relative rates of CPD removal around ORF structures in wild-type (n = 3, black) and gcn5Δ (n = 2, green) cells. Solid lines show the mean of relative CPD repair rates levels, with the shaded areas highlighting the SEM or SD, respectively. CPD levels are plotted as arbitrary units on the y-axis.