Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin

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Figure 6.
Figure 6.

Gcn5 is recruited to Abf1 binding sites and ORFs in response to UV in a Rad16-dependent manner. (A) Gcn5 binding data in wild-type cells around Abf1 binding sites for unirradiated (black; circle highlight), 0 min post-UV (dark gray; diamond highlight), 15 min post-UV (mid-gray; square highlight), and 60 min post-UV (light gray; triangle highlight) cells. Solid lines show means (n = 3, 3, 2, and 3, respectively), and shaded areas show the SEM (SD for n = 2). (B) Gcn5 binding data in rad16Δ cells around Abf1 binding sites for unirradiated (red; circle highlight), 0 min post-UV (dark pink; diamond highlight), 15 min post-UV (mid-pink; square highlight), and 60 min post-UV (light pink; triangle highlight) cells. Solid lines show the means of two data sets per time point, and shaded areas show the SD. (C) As in A, plotted around ORF structure (see Fig. 1C). (D) As in B, plotted around ORF structure (see Fig. 1C).

This Article

  1. Genome Res. 26: 1376-1387

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